The Domaine de Bonserine extends over 12 hectares of vines, mainly old Syrah called "Serine", very old varieties of Syrah, in the Côte-Rôtie appellation and on 1 hectare of Viognier vines in the Condrieu appellation.

The estate's plots are called Côte-Rôtie, Côte-Blonde, Côte-Brûne, Les Moutonnes, La Viallière, Leyat, Le Champin, Fondjean, Planèze, and in Condrieu, Les Eyguets and La Grande. Each parcel is vinified separately without yeasting, with its own indigenous yeasts.

The wines of Côte-Rôtie are made from 97% Syrah and 3% from Viognier, the white grape variety of the Condrieu appellation.