Château Saint-Georges was born in Gallo-Roman times from what was then the home of the famous Latin poet Ausonius. It overlooks the small Saint-Georges-Saint-Emilion appellation which extends over 45 hectares in a single block 3 km from Saint-Emilion and is the smallest appellation in Bordeaux. The vineyard faces the Saint-Emilion plateau, from which it is separated only by the Barbanne stream.

In 1602, the estate was sold by Henri IV to Jean Barbot, a lawyer at the Parliament of Bordeaux. The current Château dates from 1772 and is the work of the architect Victor Louis, who is also known for having built the Grand Théâtre de Bordeaux. Destroyed by phylloxera, the vineyard was replanted in 1891 by Pétrus Desbois and Château Saint-Georges is still the property of the Desbois family, associated since 2013 with Jean-Philippe Janoueix.

Château Saint-Georges is the estate's first wine and is now known all over the world. It is composed of 80% Merlot, 10% Cabernet Franc and 10% Cabernet Sauvignon and is aged in barrels for 12 to 14 months with 30 to 40% new barrels.