Domaine des Sénéchaux is a wine estate in the southern Rhône Valley in Châteauneuf-du-Pape.

It extends over 27 hectares of plots in the localities of Sénéchaux, Revès and Grand Pierre, on the plateau of the Châteauneuf-du-Pape appellation. It is one of the oldest vineyards in the appellation. Its history dates back to the 14th century and it owes its name to the main plots of the estate which are located in the Bois Sénéchaux district.

In 2006, the Domaine des Sénéchaux became the property of the Cazes family, who also owned Château Lynch-Bages in Pauillac. The Cazes family then continued the efforts undertaken since 1998 to renovate the vineyard and preserve the old Grenache vines and to modernize the cellars.