Domaine Yves Cuilleron is a wine estate located in Verlieu and which extends over 75 hectares, in several appellations in the north of the Rhône Valley, mainly in Côte-Rôtie and Saint-Joseph for red wines, Condrieu, Saint-Joseph and Saint-Péray for white wines.

Founded in 1920 by Claude Cuilleron, Yves' grandfather, the estate was taken over by the latter in 1987 with only 3.5 hectares of vines in Condrieu and Saint-Joseph at the time. The first vintage of Côte-Rôtie was born in 1988. Yves Cuilleron joined forces with Pierre Gaillard and François Villard to create Vins de Vienne in 1992 and in 2004, the Vitis Vienna association in order to promote Seyssuel wines and apply for the appellation of the vineyard. A new cellar was built in Verlieu in 1992, modernised in 1999, and the estate expanded in 2006 with vines in Saint-Péray and Cornas, and in 2012 in Crozes-Hermitage. In 2007, Yves Cuilleron opened the Bistrot de Serine in Ampuis with his winemaker friends including Jean-Michel Gerin, Pierre-Jean Villa, François Villard and Pierre Gaillard. In 2013, he teamed up with Jeff Cohn to produce a wine in California, the "Domaine des Chirats".

The year 2014 saw the replanting of old grape varieties for unique cuvées bottled for the first time in 2019, Dutif and Persan.